PLATELET RICH PLASMA (PRP)

Platelet-rich plasma (PRP) is defined as “autologous blood with concentrations of platelets above baseline levels, which contains at least seven growth factors”

PRP is taken directly from a patient’s own blood and then injected into the affected area

PRP contains growth factors that trigger localized inflammation, collagen production, and other regenerative processes

Used since 1987

PRP ADVANTAGES

• Autologous

• Relatively cheap

• Can be reproducible geographically

PRP DISADVANTAGES

• Side effects may occur, such as swelling at the injection site, increased pain and stiffness, and infection

• Unwanted products, such as white blood cells, certain cytokines, inflammatory cells, and infections can exist in the PRP

• Many questions still exist, such as:

  • Indications, i.e. when should this treatment be used?

  • If it is an effective treatment for osteoarthritis, should it be used in the early stages of osteoarthritis or only when all other options are exhausted?

  • What are the optimal concentrations of platelets and white blood cells?

  • How much platelet-rich plasma should be injected?

  • Do certain additives, such as thrombin, make the PRP more effective?

  • When and with what frequency should injections be given? Is one injection enough?

  • What is the best rehabilitation protocol to use after PRP injection?